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Kubva pane aza-BODIPY skeleton, NIR1001 inosanganisira mapoka ekupa maerekitironi (semuenzaniso, 4-N,N-diphenylaminophenyl) pa2,6-nzvimbo, ichigadzira symmetric D-π-D chimiro1. Iyi dhizaini inopfupisa iyo HOMO-LUMO gap, kushandura iyo yekunyudza peak kupfuura 1000 nm uye inosimudzira intramolecular charge transfer (ICT). MuTHF, NIR1001 inoratidza yakakwira maviri-photon absorption (TPA) muchinjiko-chikamu che37 GM, kuvandudza kaviri pamusoro pechinyakare BODIPY zvinobva. Hupenyu hwayo hwekunakidzwa hwe1.2 ps hunogonesa hunoshanda husina-radiative shanduko, ichiita kuti ive yakakodzera kune photodynamic therapy (PDT).

Zviverengero zveDFT zvinoratidza kuti nzira yekuchaja yekuchaja yeNIR1001 inosimuka kubva ku-π-electron delocalization pakati peanopa uye anobvuma zvikamu. Kugadziriswa kweMethoxy kunowedzera kuwedzera kunyura kweNIR muhwindo rephototherapeutic (650-900 nm), kuvandudza kunzwa1. Zvichienzaniswa nedhayi dzeFudan University dzeAF, NIR1001 inochengetedza huremu hudiki hwemamorekuru (<500 Da) ne40% yepamusoro yephotostability. Carboxylation gadziriso inovandudza kunyungudika kwemvura (cLogD=1.2), kuderedza kusiri-chaiyo adsorption mune biological system.

3. Biomedical Applications
Mu bioimaging, iyo hCG-conjugated probe hCG-NIR1001 inowana yakakwirira-resolution imaging ye ovarian follicles uye micro-metastases pasi pe808 nm excitation. Nekupinda kwakadzika kwemasendimita matatu muNIR-II, inokunda NIR-I probes nekatatu, uku ichidzikisa kumashure fluorescence ne60%. Mumuenzaniso wekukuvadzwa kwembeva, NIR1001 inoratidza 85% kutorwa kwerenal, kuona kukuvadzwa katanhatu nekukurumidza kupfuura macromolecular controls.
YePDT, NIR1001 inogadzira reactive okisijeni marudzi (ROS) pa 0.85 μmol/J pasi pe1064 nm laser irradiation, zvinobudirira kupinza bundu cell apoptosis. Liposome-encapsulated NIR1001 nanoparticles (NPs) inounganidza 7.2 nguva yakawanda mumamota pane yemahara dhayi, ichideredza kure-kunangwa mhedzisiro.
4. Industrial and Environmental Monitoring
Mumaindasitiri ekushandisa, NIR1001 inosanganisirwa muJuhang Technology's SupNIR-1000 analyzer yekusarudza michero, yenyama yemhando yekuongorora, uye kugadzirisa fodya. Inoshanda mu900-1700 nm renji, panguva imwe chete inoyera shuga yemukati, mwando, uye masara emishonga yezvipembenene mukati memasekonzi makumi matatu ne ± (50ppm + 5% kuverenga) iko. Mumotokari CO2 sensors (ACDS-1001), NIR1001 inogonesa chaiyo-nguva yekutarisa neT90≤25s yekupindura nguva uye 15-yemakore ehupenyu.
Nekuona kwezvakatipoteredza, NIR1001-functionalized probes inoona masimbi anorema mumvura. Mu pH 6.5-8.0, fluorescence intensity inowirirana neHg²⁺ concentration (0.1-10 μM) ine muganhu wekuona we 0.05 μM, inodarika nzira dzemavara nemirairo miviri yehukuru.
5. Technology Innovation uye Commerceization
Qingdao Topwell Zvishandisoinoshandisa inoenderera mberi kugadzira NIR1001 pa99.5% kuchena, iine 50 kg/batch kugona. Uchishandisa microchannel reactors, iyo Knoevenagel condensation nguva inoderedzwa kubva pamaawa gumi nemaviri kusvika kumaminitsi makumi matatu, ichicheka kushandiswa kwesimba ne60%. Iyo ISO 13485-yakasimbiswa NIR1001 yakatevedzana inotonga iyo biomedical musika.